who和whom和whose的用法区别如下：
一、who的用法介绍
who作为代词，意为（询问姓名、身份或职务）谁，什么人；表示所指的人；进一步提供有关某人的信息。
例句：Who is that woman?
那个女的是谁？
The people who called yesterday want to buy the house.
昨天打电话来的人想买这座房子。
And then Mary,who we had been talking about earlier,walked in.
随后玛丽走了进来，我们刚才还在谈论她呢。
She made it her business to find out who was responsible.
她一定要查清楚到底该谁负责。
Who could forget his speech at last year's party?
谁能忘记他去年在聚会上的讲话呢？
二、whom的用法介绍
whom作为代词，意为谁，什么人。与who同义，作为动词或介词的宾语。
例句：Whom did they invite?
他们邀请谁了？
To whom should I write?
我应该把信写给谁？
The author whom you criticized in your review has written a reply.
你在评论中批评的那位作者已经回信答复了。
三、whose的含义及用法介绍
whose作为代词，意为（用于问句）谁的；（特指）那个人的，哪一个的，其；进一步提供信息时用。
例句：I wonder whose this is.
我不知道这是谁的。
He's a man whose opinion I respect.
他是我尊重其意见的人。
Isobel, whose brother he was, had heard the joke before.
伊泽贝尔，就是他的兄弟，以前曾经听说过这个笑话。