give out和hand out二者都有分发的意思，但give out多指发出（气味，光线，声音，信号，热等）；hand out多指发出去、分发，也有施舍的意思。
hand out：帮助克服困难；帮助做事情，强调用手的动作；也有分发给的意思，隐含施舍的意思；give out：用尽，疲惫；分配，分发；宣布，放出（气，光，烟）；淘汰。
hand out可以当名词使用，give out只能做动词。
做分发的意思时，hand out是人作主语，意为“上交，交出”，give out是物作主语，意为“发出，散发”。
hand out是下发，比如老师发作业是Teacher handed out our homework，give out是送出，比如向慈善机构捐赠衣物是Give out clothes to charity。
give out和hand out双语例句：
1、I put my hand out towards her.
我朝她伸出手。
2、She put her hand out and skittled a row of bottles.
她伸出手，撞倒了一排瓶子。
3、Ward's hand shot out,grabbing his arm.
沃德迅速伸出手，抓住他的胳膊。
4、He went to meet them with his hand stretched out in welcome.
他伸手去欢迎他们的到来。
5、He dipped his hand into his pocket and fished out a handful of sweets.
他把手探进口袋，摸出一把糖来。
6、I've told the girls to give out that we've gone fishing.
我已让女儿说我们去钓鱼了。
7、You have to give her ten out of ten for persistence.
你得赞扬她的坚持不懈。
8、Give her the chance of a night's rest before you have it out with her.
让她休息一晚上你再当面向她说个明白。
9、Leave the hosepipe running to give the system a good flush out.
让水管不停冲水，好让这设备彻底清洗一下。
10、Give the hair a quick pull and it comes out by the roots.
猛扯头发，头发就会连根拔起。