what to do with意思是怎么做，用...做什么。
how to do with意思是如何做。
两者都可以。
what to do with造句：
The children didn't know what to do with themselves as Christmas drew near.
圣诞节即将到来，孩子们坐立不安了。
The government appears to be in a quandary about what to do with so many people.
政府似乎陷入了左右为难的境地，不知道该拿这么多人怎么办。
Was there a difference of opinion over what to do with the Nobel Prize money?
在如何利用那笔诺贝尔奖金的问题上有不同意见吗？
The play was terrible; half the actors didn't know what to do with their hands.
这个剧演得糟极了，一半演员连手都不知怎么放。
I don't know what to do with the problem.
我不知道如何处理这个问题。
how to do with造句：
How to Do with When Staff Miracle Is Low?
员工士气低落，怎么办？
Could I take up a few minutes of yours to talk about how to do with the books?
我能不能占用你几分钟来讨论一下如何来处理这些书？
Both candidates have plans for how to do with it, Tom foreman compares their ideas.
两位候选人都有如何处理赤字的计划，汤姆弗尔曼对比了他们的意见。
But how to do with the old system: by violent overthrowing or by peaceful transformation?
但是，应以何种方式对待旧政体，是用暴力推翻还是和平改造？