第1个回答 2008-04-03
Goal: Discusses XXX oral to acute cerebral hemorrhage big mouse's nerve morbid state grading, in the blood brain barrier index and the brain organization the neuron specificity enolase, the tumor necrosis factor expression influence. method: 60 grown-up male SD big mice divide into the blank control group, the model group, the Nimmo horizontal group, XXX oral large, medium and small monitoring team stochastically. Besides the blank group, other each group uses under the three-dimensional position finder from the body blood brain in pours into the model building. After the animal regains consciousness, each group defers to Bederson and so on nerve damage graduation point scale (slightly improvement), carries on nerve function flaw grading immediately. 3 point and the following animal is selected this experiment, starts to fill the stomach to the medicine, daily one time. For medicine 7 days later, the gather samples, use the brom cresol green color method determination cerebrospinal fluid, the serum albumin, the immunity group reduction examination neuron specificity enolase and the tumor necrosis factor, concrete method according to reagent box explanation. result: (after 1) in the ICH big mouse brain the haematoma forms, the animal has the nervous system symptom; (2) the model group and the blank group compare, in the brain organization NSE, TNF-α and the BBB index elevates (P obviously <0.01), prompts makes the mold to be successful; (3) XXX oral small monitoring team and the model group not obvious difference (P>0.05), explained small monitoring team to big mouse cerebral hemorrhage cerebellum organization in NSE, TNF-α the expression affects not obviously, but compares to the BBB index, P