a lot of和lots of的区别有引证用法不同、修饰词语不同等。
1、引证用法不同
lots of：lot的基本意思是“许多，大量”，在肯定句中常用于a lot of或lots of结构，可修饰可数名词，也可修饰不可数名词，其含意与many或much相同；a lot of：a lot不可作状语，修饰动词，表示数量上的“多”或“经常”，a lot和lots可用来修饰形容词或副词的比较级，表示程度。
2、修饰词语不同
a lot of：除了可以修饰可数名词也可以修饰不可数名词；例如：There was a lot of background noise.背景噪音很多；lots of：修饰可数名词；例句：Her daily life involved meeting lots of people.她在日常生活中要接触很多人。
a lot of双语例句：
1、There has been a lot of resistance to this new law.
这项新的法规已经遇到很多的抵制。
2、There's always a lot of traffic at this time of day.
每天这个时候总是有很多来往车辆。
3、We sell a lot of these to people like yourself.
我们把许多这种东西卖给您这样的人。
4、The project is still causing him a lot of problems.
这项工程现在仍然给他带来许多的麻烦。
5、The company has lost a lot of business to its competitors.
公司的许多生意都被对手夺走了。
6、They've spent a lot of money on home improvements.
他们花了很多钱装修家居。
7、There are a lot of small businesses starting up in that area.
小型企业在那一地区大量涌现。
8、A lot of work is still outstanding.
许多工作尚未完成。
9、Their visit put us to a lot of expense.
他们的来访使我们破费不小。
10、It's a lot of information to absorb all at once.
要一下子消化这么多资料，真是很难。